Life Science Applications

Temperature Control Equipment

Temperature Control Equipment

Cole-Parmer has an entire range of lab products dedicated to the manufacture of temperature control. This range of science equipment is very specific to the particular development of controlling temperature and includes, including water baths, Dri-block heaters and molecular biology products such as hybridization incubators and thermal cyclers.

 

 

Life Science Spectrophotometer

MESLO M-Drop XF Spectrophotometer + Fluorometer

This top of the line spectrophotometer can perform not only UV-Vis readings in the range of 200-800nm but also fluorescence readings. M-Drop XF features predefined programs for nucleic acids, proteins, and various colorimetric assays. The patented, motorized system gently stretches the sample column and allows for three different path lengths, providing accurate readings of samples from 0.5 to 2.0µl without dilution. The integrated fluorometer yields more accurate, sensitive and selective quantitation of nucleic acids. The blue light channel (460nm) is useful for detection of dyes.

 

      • Full-spectrum absorbance scanning and calculations of
      • 260/280 and 260/230 ratios
      • Long-life Xenon lamp with precision monochromator
      • Auto-ranging path lengths of 0.05mm, 0.2mm and 1.0mm
      • Detect up to 15,000ng/µl of dsDNA without dilution
      • Integrated fluorometer for sensitive quantitation of low concentration nucleic acids

 

Cole-Parmer Jenway Genova Bio Life Science Spectrophotometer

A simple, low cost, easy to use UV/visible spectrophotometer with a fast, responsive color touchscreen and pre-programmed methods for the measurement of nucleic acid concentration and purity, protein assays and cell density. The Genova Bio utilises diode array technology to scan the entire wavelength range (198 to 800nm) in less than 3 seconds and the narrow spectral bandwidth of 3nm, makes it ideal to identify peaks for determining nucleic acid purity. The 1024 element diode array detector coupled with a flash xenon lamp results in a long life, robust spectrophotometer.

The Proteins measurement mode can be used to calculate protein concentration by creating standard curves from protein assay kits. With pre-programmed methods for measuring Bradford, Lowry, Biuret and Bicinchoninic Acid (BCA) assays; up to 6 standards can be measured with 3 replicates of each standard to minimise any dilution errors.

The Proteins measurement mode is also pre-programmed with the Direct UV and Warburg-Christian methods to determine protein purity.The Genova Bio has a pre-programmed method for measuring optical density of bacterial cultures such as E.Coli and yeast cells. This is ideal to measure cell growth before cell harvesting.

 

Cole-Parmer Jenway 7415 Nano - Micro-volume Spectrophotometer

The 7415 Nano measures small sample volumes as low as 0.5µl with a high degree of accuracy, reproducibility and speed. Its ability to measure small sample volumes, reduces the need for dilutions and eliminates the requirement for cuvettes. Cleaning is quick and simple; wiping the read heads with a microfibre cloth removes all trace of the sample, allowing faster change over between samples, therefore increasing sample throughput.

The 7415 Nano is pre-programmed with methods for the measurement of ssDNA, dsDNA, RNA and oligonucleotide concentrations using wavelengths recorded at 260, 280 and 230nm, with an optional correction at 320nm. This measurement mode has the 260/280 and 260/230 ratios pre-programmed as well as a variable ratio option which enables up to 3 wavelengths to be entered as well as the correction wavelength.

Life Science Spectrophotometer
Automated Nucleic Extraction Systems

Automated Nucleic Extraction Systems

The purification of DNA or RNA is an early and mandatory step in many life science processes, used to detect bacteria and viruses in environmental, forensic, or clinical samples used to diagnose diseases, cancer or genetic disorder. Furthermore, automated nucleic acid extractor designed for small, medium and high throughput applications. Specialized spin tips enable efficient mixing of magnetic beads

 

The basic procedure of our nucleic acids isolations:

✔ Lysis of cell membrane
✔ Denaturation of proteins, DNA and other macromolecules
✔ Promotion of nucleic acid binding to magnetic particles
✔ Removal of impurities​
✔ Collection of purified DNA / RNA

 

Automated Nucleic Acid Purification, continuously help to improve laboratory workflows and to reduce human error.

 

TAN Bead Automated Extraction Instrument

The fully automated magnetic bead operating platforms use the magnetic rods within the equipment for nucleic acid isolation. The magnetic beads with nucleic acids adsorbed are automatically transferred from well to well for cell lysis, nucleic acid adsorption, washing, and elution. In contrast to complicated manual Spin Column operations, TANBead’s automated extraction devices provide you a walk-away solution and effort-saving approach for processing multiple samples at the same time.

 

Zinexts MagPurix ®

Zinexts MagPurix ® Liquid Handling Instrument (CE IVD) based on Magnetic Particle Extraction Technology which purifies 1 to 12 OR 24 samples. MagPurix provides an outstanding purity in its class, and delivers unbeatable results from any type of biological sample. A highly purified DNA is obligatory for many downstream applications, such as NGS, qPCR and other precise medical diagnostics today and MagPurix® has been proven to provide users superior purity from various specimen, even the less common types of samples.

This aNAP (automated Nucleic Acid Purification) solution, is made to be flexible, easy-to-use and versatile, yet, never compromise of its purification quality

 

Zinexts ZiPrep ®

An automated high-precision robotic pipetting system, specifically designed for low-volume PCR/qPCR sample preparation

 

Zinexts ZiXpress-32 ®

This reliable open Magnetic Pillar aNAP platform, based on Zinexts Life Science´s high-class Magnetic Beads ZiBeads®, will convince Scientists as well as Laboratory Managers with a reproducible performance at a low-cost oriented price structure.

 

qPCR Real Time PCR, KITS, and qPCR Workflow

DNA/RNA purification instruments and reagent products for life science, research and clinical diagnosis. PCRmax produces the ground breaking ECO 48 real time PCR platform. With its Patented thermal engine and detection system it offers new standards in performance, simplicity and detection for all qPCR applications.

Primer Design SNPsig SARS-CoV-2 VOC Identification Kits use genotyping method to enable the identification of SARS-CoV-2 variants of concern. These products can be used on any real-time PCR machine using familiar protocols, whilst resulting in exceptional genotyping data. 

 

PRIMER DESIGN

We offer over 550 genesig qPCR kits for pathogen detection, veterinary testing, meat speciation and much much more, including our kits which provide a pivotal role in screening forall variants of SARS-CoV-2 

 

TAN BEAD Reagent Kits

TANBead reagent kits are widely used in DNA/RNA extractions from samples of blood, cell, tissue, plant, bacteria, and virus etc. Our pre-filled reagents provide you a ready-to-use solution that there are in a selection of Auto Plate and Auto Tube which fulfills any kind of sample number requirements in your experiments.

qPCR Real Time PCR, KITS, and qPCR Workflow
Gel Documentation Systems

Gel Documentation Systems

Cleaver Scientific supplies a range of gel documentation systems, from our entry level microDOC Basic up to the all-in-one DNA and protein imaging omniDOC.The omniDOC system presents a simple but sophisticated imaging solution, whilst offering many of the features incorporated within the highest specification systems, but without the added price. The omniDoc is suitable for imaging most fluorescent and colorimetric gels, with a high resolution 5 mega pixel CMOS sensor with slide-out UV transilluminator and optional blue epiillumination module and white light table.

Cleaver Scientific also supplies a range of chemiluminescence documentation systems for both chemi and fluoresense imaging. All systems include intuitive acquisition and analysis software to make capturing and analysing gels as easy as possible.Finally we distribute the class-leading UVITEC Imaging systems for advanced image aquisition and analysis.

 

Electrophoresis

A complete range of Gel Electrophoresis systems

 

Horizontal Gel Systems
long-established technique, horizontal gel electrophoresis offers many advantages for nucleic acid separation Cleaver Scientific’s multiSUB horizontal gel electrophoresis units have been designed by scientists with the laboratory environment in mind.Our multiSUB Horizontal Electrophoresis tanks provide an easy to use and flexible platform for all your horizontal electrophoresis requirements.With a wide range of tanks and tray sizes as well as many comb options, these systems can handle all manner of electrophoresis experiments. multiSUB series of Horizontal Gel Units offers the most versatile solution for DNA and RNA agarose gel electrophoresis currently on the market. The MSMINI, MSMIDI, MSCHOICE, MSCHOICEST, MSMAXI, MSSCREEN, miniRAPIDE, MSMIDI96 and the miniONE alloffer an unsurpassed combination of gel and buffer volume, with gel size and sample number versatility.

 

Vertical Electrophoresis Systems
Cleaver Scientific provides a comprehensive range of vertical electrophoresis systems- complete with tanks inserts and reagents- to fulfil a variety of applications and techniques in different gel sizes and throughputs. The omniPAGE range comprises three sizes of gel chamber, Mini 10 x 10cm, Mini Wide 20 x 10cm and WAVE Maxi 20 x 20cm. Each system have a guaranteed leak proof seal resulting in trouble free and rapid gel casting.These systems are ideal for running precast or handcast polyacrylamide gels for SDS-PAGE or Native PAGE. Each gel tank system includes a leak free casting option to cast your own polyacrylamide gels and the omniPAGE mini can utilise a wide variety of commercially available precast gels from all major manufacturers.

 

Power Supplies
Whether you require a power supply for routine horizontal DNA agarose gel electrophoresis, or for techniques as technically demanding as SSCP analysis within a large format vertical, or first dimension IEF using IPG strips, Cleaver Scientific can meet your requirements with its comprehensive range of power supplies. Each power supply has a compact design, which means a small footprint in the laboratory, while explanatory self-prompting menus make set up easy. Furthermore, these power supplies adhere to IEC 61010 – one of the world’s most stringent electrical safety standards. Our Power supplies feature a standard 4mm banana plug style connector for compatibility with both our own electrophoresis tanks, and those of other manufacturers.

 

Electrophoresis
Equipment for concentrating viruses from liquids

Equipment for concentrating viruses from liquids

The Innovaprep Concentrating Pipette (CP) Select™, uses dead-end filtration on high-flow single-use pipette tips to capture target particles. The Innovaprep CP Select uses an automated recovery process, termed, Wet Foam Elution™ to enable efficient extraction of the particles from the filter membrane in seconds and can administer very precise and controlled amounts of foam that produce filter elution volumes as low as 200 microliters. The process maximizes the concentration of the target thereby exponentially improving the limit of detection for trace pathogens.

InnovaPrep's FluidPrep™ technologies including the Large Volume Concentration (LVC) Kit and the CP Select have been used to concentrate microorganisms including viruses in liquid matrices from a variety of environmental sources such as marine recreational and aquaculture waters, surface waters, storm run-off, cave and spring waters, irrigation waters, as well as wastewater influent and effluent. The Concentrating Pipette pairs with perfectly with most molecular methods including PCR and sequencing.

 

Wastewater Based Epidemiology using the CP Select

Public health labs, testing services labs, universities, and the military are using wastewater as a means to detect the emergence or spread of COVID-19 outbreaks which has proven to be a significant epidemiological method to help determine where to mobilize resources and determine the degree and duration of intervention needed in a community by community real-time approach.

The Concentrating Pipette effectively concentrates SARS-CoV-2 from wastewater influent faster, easier, and better than other methods by improving the limit of detection, reducing inhibition, simplifying workflow, and by reducing labor. The instrument fits into BSL-2 safety cabinets for increased ease and safety.